Insulin and Hypothalamo-Pituitary Adrenal System
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چکیده
منابع مشابه
Spinal and supraspinal analgesic effects of Nimodipine : The role of Hypothalamo-Pituitary-Adrenal(HPA) axis .
Nimodipine, an L-type calcium channel blocker, can induce analgesia. However, it is not clear that this analgesic effect is at the level of spinal or supraspinal pain pathway. In addition, it has been reported that the analgesic effect of nifedipine, another L-type calcium channel blocker is related to the HPA axis, but there is no report indicating the role of this axis in the analgesic eff...
متن کاملInsulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses.
Diabetes is associated with increased basal hypothalamo-pituitary-adrenal (HPA) activity and impaired stress responsiveness. Previously, we demonstrated that the HPA response to hypoglycemia is significantly impaired in diabetic rats. In this study our goals were to 1) differentiate between the effects of hyperinsulinemia and those of hypoglycemia per se, and 2) establish whether diabetes lower...
متن کاملThe hypothalamo-pituitary-adrenocortical system.
Control of the secretion of ACTH appears to involve several mechanisms. It is dependent upon the release, from neurones in the hypothalamus, of corticotrophin releasing factor, which is probably a complex including CRF-41 and vasopressin. The secretion of the complex is influenced by various central inhibitory and excitatory nervous pathways. The releasing factor is conveyed by the hypophyseal ...
متن کاملHypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.
Inflammation-related dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is central to the course of systemic inflammatory response syndrome or sepsis. The underlying mechanisms, however, are not well understood. Initial activation of adrenocortical hormone production during early sepsis depends on the stimulation of hypothalamus and pituitary mediated by cytokines; in late sepsis, t...
متن کاملMolecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment.
Increased hypothalamo-pituitary-adrenocortical (HPA) activity in diabetes is likely important in the development of some pathologies associated with the disorder. We hypothesized that central regulation of HPA activity differs among normal, streptozotocin (STZ)-diabetic, and insulin-treated diabetic rats. Blood glucose, ACTH, and corticosterone were elevated, 8 d after inducing diabetes. Insuli...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1955
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.31.9_503